Nonsteroidal anti-inflammatory drug-induced gastrointestinal toxicity: new insights into an old problem

J Gastroenterol. 1997 Feb;32(1):127-33. doi: 10.1007/BF01213310.


Nonsteroidal anti-inflammatory drugs are widely used for the treatment of chronic arthropathies, but their gastrointestinal damage remains a significant limitation to their use. In this review, the pathogenic mechanisms through which these drugs are believed to cause gastrointestinal damage are outlined. A better understanding of the pathogenesis of gastric and intestinal injury has resulted in novel strategies that are being employed to develop nonsteroidal anti-inflammatory drugs that do not have significant adverse effects on the gastrointestinal tract.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Digestive System / drug effects*
  • Duodenum / drug effects
  • Humans
  • Intestine, Small / drug effects
  • Stomach / drug effects


  • Anti-Inflammatory Agents, Non-Steroidal