Osteonecrosis and human immunodeficiency virus infection

J Rheumatol. 1997 Mar;24(3):601-4.


We reviewed the clinical records of 6 patients with osteonecrosis and human immunodeficiency virus (HIV) infection. We conducted a literature search for the putative mechanism by which this association may occur. None of these 6 patients had other known conditions associated with a predisposition to osteonecrosis. Avascular necrosis (AVN) frequently occurred in multiple sites and early in the course of HIV infection. We suggest that HIV infection is a systemic disorder that may predispose to osteonecrosis of bone. The most likely mechanism involves thrombosis, which may be mediated by anticardiolipin antibodies and/or acquired deficiency of protein S. In patients with idiopathic osteonecrosis that involves multiple sites we recommend careful evaluation for HIV risk factors.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • HIV Infections / complications*
  • Humans
  • Male
  • Osteonecrosis / complications*