Severe lactic acidosis and neonatal death in Pearson syndrome

J Inherit Metab Dis. 1997 Mar;20(1):43-8. doi: 10.1023/a:1005305422544.


Pearson marrow-pancreas syndrome, a fatal disease associated with mitochondrial DNA rearrangements, is characterized by refractory sideroblastic anaemia during infancy. Only a few neonates with Pearson syndrome have been reported with metabolic acidosis. A female neonate who exhibited severe metabolic acidosis and anaemia at birth is described here. Her condition progressively worsened, with pancytopenia and uncontrollable metabolic acidosis resulting in death at the age of 14 days. A 4988-base pair deletion of mtDNA was detected in the patient's leukocytes, liver and muscle. When a neonate exhibits severe metabolic acidosis of unknown cause, the possibility of Pearson syndrome should be considered.

Publication types

  • Case Reports

MeSH terms

  • Acidosis, Lactic / genetics*
  • Acidosis, Lactic / mortality
  • Acidosis, Lactic / physiopathology
  • Bone Marrow Diseases / genetics*
  • Bone Marrow Diseases / mortality
  • Bone Marrow Diseases / physiopathology
  • DNA, Mitochondrial*
  • Fatal Outcome
  • Female
  • Humans
  • Infant, Newborn
  • Pancreatic Diseases / genetics*
  • Pancreatic Diseases / mortality
  • Pancreatic Diseases / physiopathology
  • Sequence Deletion
  • Syndrome


  • DNA, Mitochondrial