Bcl-2 overexpression in basaloid proliferations overlying dermatofibromas and basal cell carcinomas

APMIS. 1997 Jan;105(1):35-40. doi: 10.1111/j.1699-0463.1997.tb00537.x.

Abstract

Basaloid proliferations overlying dermatofibromas resembling superficial basal cell carcinomas have been interpreted both as reactive/regressive and frankly malignant. Basal cell carcinoma is a slow-growing tumour, which so far has been regarded as an actively proliferating lesion with a high apoptotic activity. We examined immunohistochemically 6,dermatofibromas with overlying simple hyperplasia, 12 dermatofibromas with overlying basaloid proliferations, and 24 basal cell carcinomas for expression of Ki-67 protein, and bcl-2 protein. The Ki-67 labelling index represents an estimate of proliferative activity. Bcl-2 protein suppresses apoptosis. The Ki-67 labelling indexes of basaloid proliferations, basal cell carcinomas, and normal epidermis were similar (11-15%, p < 0.05, Mann-Whitney test). Bcl-2 protein was expressed in all cells of basaloid proliferations, similar to the expression pattern in basal cell carcinomas. We suggest that basaloid proliferations overlying dermatofibromas might have achieved a phenotype that equals an early stage of BCC carcinogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Basal Cell / metabolism*
  • Epidermis / metabolism
  • Histiocytoma, Benign Fibrous / metabolism*
  • Humans
  • Hyperplasia / metabolism
  • Immunoenzyme Techniques
  • Ki-67 Antigen / biosynthesis
  • Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
  • Skin Neoplasms / metabolism*

Substances

  • Ki-67 Antigen
  • Proto-Oncogene Proteins c-bcl-2