Prognostic value of cathepsins B, D and steffins A and B in laryngeal carcinoma

Eur Arch Otorhinolaryngol. 1997;254 Suppl 1:S150-3. doi: 10.1007/BF02439748.

Abstract

Concentrations of cathepsins A, D and stefins A and B were measured in primary tumor and adjacent normal tissue of 25 patients with laryngeal carcinoma. Median concentrations of both cathepsins and that of stefin B were significantly higher in tumor tissue than in their normal counterparts (cathepsins B and D, P < 0.0001; stefin B, P = 0.01), indicating their possible involvement in the process of tumor spread. Early (T1 and T2) tumors had lower concentrations of stefins A and B than locally advanced (T3 and T4) tumors (P = 0.04). Disease-free and disease-specific survival rates at 45 months were significantly better in patients with tumor concentrations of stefins above or equal to the cut-off values (stefin A, P = 0.001 and P = 0.004; stefin B, P = 0.048 and P = 0.008), indicating that these might be of prognostic value. The concentrations of cathepsins B and D did not correlate with survival.

MeSH terms

  • Adult
  • Aged
  • Biomarkers, Tumor / analysis
  • Carcinoma, Squamous Cell / enzymology*
  • Carcinoma, Squamous Cell / pathology
  • Cathepsin B / analysis*
  • Cathepsin D / analysis*
  • Cystatin A
  • Cystatin B
  • Cystatins / analysis*
  • Cysteine Proteinase Inhibitors / analysis*
  • Disease-Free Survival
  • Humans
  • Laryngeal Neoplasms / enzymology*
  • Laryngeal Neoplasms / pathology
  • Larynx / enzymology
  • Larynx / pathology
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local / enzymology
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Staging
  • Prognosis
  • Survival Rate

Substances

  • Biomarkers, Tumor
  • CSTB protein, human
  • Cystatin A
  • Cystatins
  • Cysteine Proteinase Inhibitors
  • CSTA protein, human
  • Cystatin B
  • Cathepsin B
  • Cathepsin D