Chaperones get in touch: the Hip-Hop connection

Trends Biochem Sci. 1997 Mar;22(3):87-92. doi: 10.1016/s0968-0004(97)01005-0.


Recent findings emphasize that different molecular chaperones cooperate during intracellular protein biogenesis. Mechanistic aspects of chaperone cooperation are now emerging from studies on the regulation of certain signal transduction pathways mediated by Hsc70 and Hsp90 in the eukaryotic cytosol. Efficient cooperation appears to be achieved through a defined regulation of Hsc70 activity by the chaperone cofactors Hip and Hop.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacterial Proteins / metabolism*
  • HSP70 Heat-Shock Proteins / metabolism
  • Humans
  • Molecular Chaperones / metabolism*
  • Molecular Sequence Data
  • Signal Transduction


  • Bacterial Proteins
  • HSP70 Heat-Shock Proteins
  • Hip chaperone
  • Molecular Chaperones
  • Streptomyces trypsin inhibitor 1 protein, Streptomyces