Transcription factors vs nucleosomes: regulation of the PHO5 promoter in yeast

Trends Biochem Sci. 1997 Mar;22(3):93-7. doi: 10.1016/s0968-0004(97)01001-3.

Abstract

Activation of the Saccharomyces cerevisiae PHO5 gene is accompanied by the disruption of four positioned nucleosomes at the promoter. The chromatin transition requires a DNA-binding protein, Pho4, and its transactivation domain. The mechanism of nucleosome disruption and the contribution of the nucleosomes to PHO5 regulation are reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chromatin / chemistry
  • Chromatin / metabolism
  • Chromatin / ultrastructure
  • Chromosomal Proteins, Non-Histone / genetics
  • Chromosomal Proteins, Non-Histone / metabolism
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation, Fungal*
  • Membrane Transport Proteins / genetics*
  • Nucleosomes / chemistry
  • Nucleosomes / genetics
  • Nucleosomes / metabolism*
  • Phosphate Transport Proteins*
  • Promoter Regions, Genetic
  • Saccharomyces cerevisiae Proteins*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Transcription, Genetic

Substances

  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Membrane Transport Proteins
  • Nucleosomes
  • Phosphate Transport Proteins
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • phosphate permease
  • SPT2 protein, S cerevisiae