Fixed drug eruption of the penis due to hydroxyzine hydrochloride

Ann Pharmacother. 1997 Mar;31(3):327-9. doi: 10.1177/106002809703100311.


Objective: To report four cases of fixed drug eruption induced by hydroxyzine hydrochloride (Otarex, Teva, Israel).

Case summary: Four children with restlessness who were treated with hydroxyzine hydrochloride developed fixed drug eruption of the penis. Drug discontinuation was followed by complete resolution of the skin eruption. Rechallenge resulted in the same drug rash. Macrophage migration inhibiting factor (MIF) assay with hydroxyzine hydrochloride was positive.

Discussion: The pathogenesis of fixed drug eruption and the role of macrophage MIF assay in diagnosis is discussed.

Conclusions: A fixed drug eruption induced by hydroxyzine hydrochloride is possible, but is a rare phenomenon.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Anti-Anxiety Agents / adverse effects*
  • Anti-Anxiety Agents / therapeutic use
  • Child
  • Drug Eruptions* / immunology
  • Guinea Pigs
  • Humans
  • Hydroxyzine / adverse effects*
  • Hydroxyzine / therapeutic use
  • Infant
  • Macrophage Migration-Inhibitory Factors / analysis
  • Male
  • Penis*
  • Psychomotor Agitation / drug therapy*


  • Anti-Anxiety Agents
  • Macrophage Migration-Inhibitory Factors
  • Hydroxyzine