Peroxidative damage in sickle-cell erythrocyte ghosts: protective effect of allopurinol

Gen Pharmacol. 1997 Mar;28(3):427-8. doi: 10.1016/s0306-3623(96)00297-2.

Abstract

1. Malondialdehyde (MDA) levels of erythrocyte membranes of sickle-cell disease patients were measured as an indicator of peroxidative damage and allopurinol was used as a lipid peroxide scavenger. 2. Incubating sickle-cell erythrocytes with allopurinol significantly reduced MDA levels of erythrocyte membranes compared with before-treatment values. 3. Allopurinol seems to reduce the peroxidative damage in sickle-cell erythrocytes, but the mechanism is still unknown.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Allopurinol / pharmacology*
  • Anemia, Sickle Cell / blood*
  • Antioxidants / pharmacology*
  • Blood Cell Count
  • Erythrocyte Membrane / drug effects*
  • Erythrocyte Membrane / metabolism
  • Female
  • Humans
  • Lipid Peroxidation / drug effects*
  • Male
  • Malondialdehyde / analysis

Substances

  • Antioxidants
  • Malondialdehyde
  • Allopurinol