Investigations on the protective action of Condonopsis pilosula (Dangshen) extract on experimentally-induced gastric ulcer in rats

Gen Pharmacol. 1997 Mar;28(3):469-73. doi: 10.1016/s0306-3623(96)00047-x.


The action of Codonopsis pilosula extract in 5 animal models of gastric ulcer was investigated. It was found that the extract had higher efficacy on gastric ulcer induced by stress, acetic acid and sodium hydroxide and little significant effect on ulcers induced by pyloroligature and indomethacin. The C. pilosula extract was also capable of reducing gastric acid pepsin secretion. It is possible that inhibition of gastrointestinal movement and propulsion is one of the mechanisms underlying the antiulcer action of C. pilosula extract.

Publication types

  • Comparative Study

MeSH terms

  • Acetic Acid
  • Animals
  • Anti-Ulcer Agents / therapeutic use*
  • Drugs, Chinese Herbal / therapeutic use*
  • Duodenum / drug effects
  • Duodenum / physiology
  • Gastric Acid / metabolism
  • Gastric Mucosa / drug effects*
  • Gastric Mucosa / metabolism
  • Gastrointestinal Motility / drug effects
  • Indomethacin
  • Mice
  • Pepsin A / metabolism
  • Rabbits
  • Rats
  • Rats, Sprague-Dawley
  • Stomach Ulcer / drug therapy*
  • Stomach Ulcer / etiology
  • Stomach Ulcer / pathology
  • Stress, Physiological


  • Anti-Ulcer Agents
  • Drugs, Chinese Herbal
  • Pepsin A
  • Acetic Acid
  • Indomethacin