Preliminary study of glycopyrrolate in the management of drooling

J Paediatr Child Health. 1997 Feb;33(1):52-4. doi: 10.1111/j.1440-1754.1997.tb00991.x.


Objective: A study was undertaken to assess the efficacy of an oral anticholinergic drug, glycopyrrolate, in the management of drooling in children and young adults with disabilities.

Methodology: Glycopyrrolate was used by 24 children and young adults for up to 28 months. Parents/carers were asked to complete a questionnaire on the effects of the drug on severity and frequency of drooling and to report any side-effects.

Results: Twenty-two questionnaires were returned. There was a statistically significant decrease in both severity and frequency of drooling with minimal side-effects reported.

Conclusion: In this preliminary study, glycopyrrolate was found to be an effective and well-tolerated addition to the management of drooling in children with disabilities.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Cholinergic Antagonists / adverse effects
  • Cholinergic Antagonists / therapeutic use*
  • Disabled Persons
  • Female
  • Glycopyrrolate / adverse effects
  • Glycopyrrolate / therapeutic use*
  • Humans
  • Male
  • Sialorrhea / drug therapy*
  • Treatment Outcome


  • Cholinergic Antagonists
  • Glycopyrrolate