A new family of G-protein regulators - the RGS proteins

Curr Opin Cell Biol. 1997 Apr;9(2):143-7. doi: 10.1016/s0955-0674(97)80055-5.


Genetic experiments have recently been used to identify a family of 'regulator of G-protein signaling' (RGS) proteins, which downregulate signaling by heterotrimeric G proteins. The first biochemical studies of RGS proteins have shown that they accelerate the GTPase activities of G-protein alpha subunits, thus driving G proteins into their inactive GDP-bound forms. The physiological significance of the large number of different RGS proteins remains to be explored.

Publication types

  • Review

MeSH terms

  • Animals
  • Enzyme Activation
  • GTP Phosphohydrolases / metabolism*
  • GTP-Binding Proteins / metabolism*
  • Humans
  • Proteins / metabolism*
  • Signal Transduction


  • Proteins
  • GTP Phosphohydrolases
  • GTP-Binding Proteins