How receptors talk to trimeric G proteins

Curr Opin Cell Biol. 1997 Apr;9(2):134-42. doi: 10.1016/s0955-0674(97)80054-3.


Stimulated by hormones and sensory stimuli, serpentine receptors promote the release of GDP that is bound to the alpha subunit of trimeric G proteins and its replacement by GTP. Recent investigations have begun to define the sizes, shapes, and relative orientations of receptors and G proteins, the surfaces through which they interact with one another, and conformational changes in both sets of molecules that underlie receptor-catalyzed guanine-nucleotide exchange.

Publication types

  • Review

MeSH terms

  • Animals
  • GTP-Binding Proteins / chemistry
  • GTP-Binding Proteins / metabolism*
  • Guanosine Diphosphate / metabolism
  • Humans
  • Molecular Conformation
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / metabolism*


  • Receptors, Cell Surface
  • Guanosine Diphosphate
  • GTP-Binding Proteins