The state of the STATs: recent developments in the study of signal transduction to the nucleus

Curr Opin Cell Biol. 1997 Apr;9(2):233-9. doi: 10.1016/s0955-0674(97)80067-1.


The STATs (signal transducers and activators of transcription) are latent cytoplasmic proteins that, upon activation by cell surface bound polypeptide ligands, move to the nucleus to direct transcription. A variety of protein-protein interactions that affect the function of STATs has been recently recognized. It has become clear that the STATs are functional mosaics, or mixtures of signal transduction and transcription modules.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • Cell Nucleus / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Humans
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinases*
  • STAT1 Transcription Factor
  • Signal Transduction*
  • Trans-Activators / metabolism*
  • src Homology Domains


  • DNA-Binding Proteins
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • Trans-Activators
  • Calcium-Calmodulin-Dependent Protein Kinases
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinases