Nuclear receptor coactivators

Curr Opin Cell Biol. 1997 Apr;9(2):222-32. doi: 10.1016/s0955-0674(97)80066-x.


Retinoic acid, steroid and thyroid hormones regulate complex programs of gene expression by binding to intracellular receptors that are members of the nuclear receptor superfamily of ligand-dependent transcription factors. Recent studies have led to the identification and cloning of genes encoding coactivator molecules that appear to play important roles in mediating ligand-dependent transcription by members of this family. The identification of these coactivator molecules suggests a point of entry into the general transcriptional machinery that is common to several other classes of regulated transcription factors.

Publication types

  • Review

MeSH terms

  • Allosteric Regulation
  • Animals
  • CREB-Binding Protein
  • Histone Acetyltransferases
  • Humans
  • Nuclear Proteins / metabolism
  • Nuclear Receptor Coactivator 1
  • Nuclear Receptor Coactivator 2
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Signal Transduction
  • Trans-Activators*
  • Transcription Factors / metabolism*


  • Nuclear Proteins
  • Nuclear Receptor Coactivator 2
  • Receptors, Cytoplasmic and Nuclear
  • Trans-Activators
  • Transcription Factors
  • CREB-Binding Protein
  • CREBBP protein, human
  • Histone Acetyltransferases
  • NCOA1 protein, human
  • Nuclear Receptor Coactivator 1