Reversible palmitoylation of signaling proteins

Curr Opin Cell Biol. 1997 Apr;9(2):148-54. doi: 10.1016/s0955-0674(97)80056-7.


Palmitoylation is unique among lipid modifications of proteins in that it is reversible and regulable. Recent advances in the study of palmitoylation include the following: the correlation of this modification with the localization of a signaling protein to specific membrane subdomains; the demonstration of a specific protein-protein interaction that is promoted by palmitoylation; and the identification, characterization, and purification of enzymes catalyzing this modification.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Membrane / metabolism
  • GTP-Binding Proteins / metabolism
  • Palmitic Acid / metabolism*
  • Receptors, Cell Surface / metabolism
  • Signal Transduction*


  • Receptors, Cell Surface
  • Palmitic Acid
  • GTP-Binding Proteins