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Review
, 9 (2), 174-9

The Complexity of Raf-1 Regulation

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Review

The Complexity of Raf-1 Regulation

D K Morrison et al. Curr Opin Cell Biol.

Abstract

The activation of the serine/threonine kinase Raf-1 is proving to be an intricate multistep process. Recent advances in elucidating how Raf-1 becomes activated in response to signaling events have emphasized the role of phosphorylation and protein interactions in Raf-1 regulation. The picture clearly emerging is that Raf-1 activity can be regulated by multiple mechanisms.

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