Transducing signals of life and death

Curr Opin Cell Biol. 1997 Apr;9(2):247-51. doi: 10.1016/s0955-0674(97)80069-5.


The molecules that form signaling complexes with the cytoplasmic domains of tumor necrosis factor (TNF) receptors (TNF-Rs) and CD95 have been identified recently. The death-signaling pathways induced by TNF-R1 and CD95 involve a group of death domain containing proteins, including caspase-8, a member of the interleukin-1beta-converting enzyme family. TNF-R1 and TNF-R2 also interact with the members of both the TNF-R associated factor family and the inhibitor of apoptosis protein family; these interactions lead to cell survival.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Cell Survival / physiology
  • Fas Ligand Protein
  • Humans
  • Membrane Glycoproteins / metabolism*
  • Receptors, Tumor Necrosis Factor / metabolism*
  • Signal Transduction*
  • Tumor Necrosis Factor-alpha / metabolism*
  • fas Receptor / metabolism*


  • FASLG protein, human
  • Fas Ligand Protein
  • Membrane Glycoproteins
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor-alpha
  • fas Receptor