Nef and PAK: virulence factor and cellular accomplice

Chem Biol. 1997 Jan;4(1):13-5. doi: 10.1016/s1074-5521(97)90232-5.

Abstract

The Nef protein is important in HIV replication and in AIDS pathogenesis. The finding that Nef activates a member of the PAK family of protein kinases provides new insights into the mechanisms of action of this critical virulence factor.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / physiopathology
  • Animals
  • Gene Products, nef / metabolism*
  • Genes, nef
  • HIV-1 / genetics
  • HIV-1 / pathogenicity*
  • Humans
  • Macaca mulatta
  • Models, Biological
  • Protein Serine-Threonine Kinases / metabolism*
  • Simian Acquired Immunodeficiency Syndrome / physiopathology
  • Simian Immunodeficiency Virus / genetics
  • Simian Immunodeficiency Virus / pathogenicity*
  • Virulence
  • nef Gene Products, Human Immunodeficiency Virus

Substances

  • Gene Products, nef
  • nef Gene Products, Human Immunodeficiency Virus
  • Protein Serine-Threonine Kinases