Abstract
The Nef protein is important in HIV replication and in AIDS pathogenesis. The finding that Nef activates a member of the PAK family of protein kinases provides new insights into the mechanisms of action of this critical virulence factor.
MeSH terms
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Acquired Immunodeficiency Syndrome / physiopathology
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Animals
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Gene Products, nef / metabolism*
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Genes, nef
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HIV-1 / genetics
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HIV-1 / pathogenicity*
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Humans
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Macaca mulatta
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Models, Biological
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Protein Serine-Threonine Kinases / metabolism*
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Simian Acquired Immunodeficiency Syndrome / physiopathology
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Simian Immunodeficiency Virus / genetics
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Simian Immunodeficiency Virus / pathogenicity*
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Virulence
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nef Gene Products, Human Immunodeficiency Virus
Substances
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Gene Products, nef
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nef Gene Products, Human Immunodeficiency Virus
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Protein Serine-Threonine Kinases