Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors

Biochem Biophys Res Commun. 1997 Feb 24;231(3):651-4. doi: 10.1006/bbrc.1997.6161.


We have used PCR with degenerate oligonucleotide primers to clone novel members of the G protein-coupled receptor (GPCR) superfamily. We report here a novel gene, CEPR, which encodes a candidate receptor that is most similar to the peptide receptor family. The coding region of the human CEPR gene predicts a seven transmembrane domain (TM) receptor of 375 amino acids. CEPR has 28-30 percent amino acid identity to angiotensin II and interleukin 8 receptors, and slightly lower percent identity to many other GPCRs. Northern blot analysis reveals a 3.3 kb CEPR transcript in different regions of human brain and in various peripheral tissues. The ubiquitous tissue distribution of CEPR, its expression in early development, and its conservation in evolution indicate a potentially important biological function for this receptor and its putative peptide ligand.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • GTP-Binding Proteins / physiology
  • Gene Expression
  • Genes
  • Humans
  • Membrane Glycoproteins / metabolism
  • Molecular Sequence Data
  • RNA, Messenger / genetics
  • Receptors, Peptide / genetics*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Tissue Distribution


  • Membrane Glycoproteins
  • RNA, Messenger
  • Receptors, Peptide
  • GTP-Binding Proteins

Associated data

  • GENBANK/I38710
  • GENBANK/U77827