T-cell receptors: feeling out the complex

Curr Biol. 1997 Jan 1;7(1):R17-20. doi: 10.1016/s0960-9822(06)00010-8.


Recent crystallographic studies show that the T-cell receptor has a largely immunoglobulin-like structure and binds to MHC-peptide complexes through loops from paired Valpha and Vbeta domains that focus on the central amino acids of the MHC-bound peptide, and to bacterial superantigens via peripheral aspects of the Vbeta domain.

MeSH terms

  • Humans
  • Immunoglobulins / chemistry
  • Major Histocompatibility Complex / immunology
  • Receptors, Antigen, T-Cell / chemistry*


  • Immunoglobulins
  • Receptors, Antigen, T-Cell