Seventy-one children with mite-sensitive asthma were randomly divided into three groups. Group 1 was comprised of 28 patients who were provided with new Microstop-treated bedding including matresses, quilts, pillows, bed linens and quilt covers. The Microstop mattresses and pillows were made of impermeable Polyurethane coated nylon ticking. Group 2 included 28 patients who were provided with new, conventional, mat Polyurethane mattresses, quilts, pillows, bed linens and quilt covers made of cotton and polyester which had not been Microstop treated. Group 3 included 15 patients who used their old bedding. Mite counts were performed on samples of dust collected from the old mattresses, pillows and quilts before the bedding was changed. After changing the bedding, mite counts were performed on dust from the same three bed sites at the end of months 1, 2, 3, 6, 9, and 12. Morning and evening peak expiratory flow, asthma symptom scores, were recorded by each patient at least 1 month before entering the study and every month during the one-year study period. Mattress mite counts were significantly reduced in Group 1 but not in Groups 2 or 3. However, quilt mite counts were significantly reduced in both Group 1 and Group 2 throughout the 12-monthstudy while mite counts in Group 3 quilts remained unchanged. The results provide evidence that the PU-coated nylon material was effective in reducing house dust mites, but do not demonstrate that the Microstop treatment had an obvious anti-mite effect. One-year follow-up of asthma symptom scores showed significant improvement in Group 1, but not in Groups 2 or 3. This suggests that the Microstop-treated bedding, as a system, was effective in asthma prevention.