Parvovirus B19-associated haemophagocytic syndrome with lymphadenopathy resembling histiocytic necrotizing lymphadenitis (Kikuchi's disease)

Br J Haematol. 1997 Mar;96(4):868-71. doi: 10.1046/j.1365-2141.1997.d01-2099.x.


A 15-year-old girl developed a haemophagocytic syndrome caused by human parvovirus B19 (PVB19). The cervical lymph node histology, resembling that of histiocytic necrotizing lymphadenitis (HNL, Kikuchi's disease), included several transformed lymphocytes, numerous histocytes, and massive necrosis. We detected PVB19-positive cells in the lymph node by immunohistochemistry. Possible autoimmune mechanisms in HNL-like diseases triggered by PVB19 are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Female
  • Histiocytosis, Non-Langerhans-Cell / drug therapy
  • Histiocytosis, Non-Langerhans-Cell / virology*
  • Humans
  • Immunohistochemistry
  • Lymphadenitis / drug therapy
  • Lymphadenitis / virology*
  • Necrosis
  • Parvoviridae Infections / complications*
  • Parvoviridae Infections / drug therapy
  • Parvovirus B19, Human
  • Prednisolone / therapeutic use
  • Syndrome


  • Prednisolone