Renal K+ channels: structure and function

Annu Rev Physiol. 1997;59:413-36. doi: 10.1146/annurev.physiol.59.1.413.


The activity of potassium (K+) channels is intimately linked to several important transport functions in renal tubules. We review recent progress concerning the properties, site along the nephron, and physiological regulation of native K+ channels, and compare their characteristics with those of recently cloned K+ channels. We do not fully cover work on K+ channels in amphibian tubules, cell cultures, and single tubule cells and do not review K+ channels in mesangial cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Kidney / metabolism*
  • Kidney Tubules, Collecting / cytology
  • Kidney Tubules, Collecting / metabolism
  • Kidney Tubules, Proximal / metabolism
  • Loop of Henle / metabolism
  • Molecular Conformation
  • Potassium Channels / chemistry*
  • Potassium Channels / metabolism
  • Potassium Channels / physiology*
  • Structure-Activity Relationship


  • Potassium Channels