Chemical activators of sensory neurons

Annu Rev Physiol. 1997;59:457-82. doi: 10.1146/annurev.physiol.59.1.457.


Chemical activation of sensory neurons plays an important role in the somatosensory system. The actions of both endogenous mediators such as excitatory amino acids, acetylcholine, bradykinin, and ATP, as well as selective exogenous activators of nociceptive sensory neurons are reviewed. The physiological significance of these mediators in both nociception and other types of sensation are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Ion Channel Gating
  • Ion Channels / metabolism
  • Ligands
  • Neurons, Afferent / metabolism
  • Neurons, Afferent / physiology*
  • Receptors, Cell Surface / metabolism
  • Stimulation, Chemical


  • Ion Channels
  • Ligands
  • Receptors, Cell Surface