A serial CT scan and MRI verification of diffuse cerebrospinal gliomatosis: a case report with stereotactic diagnosis and radiological confirmation

Pediatr Neurosurg. 1996 Aug;25(2):94-9. doi: 10.1159/000121103.


Gliomatosis cerebri is an infrequent tumor of neuroepithelial origin presenting with deterioration of cognitive functions, behavioral and mental changes, motor weakness, headache, and seizures. Laboratory data are unconclusive. MRI appears to be the imaging modality of choice and mainly reveals a bilateral and diffuse infiltration of midline adjacent brain structures whose anatomical configuration remain intact. MRI- or CT-guided stereotactic biopsy is advised as the diagnostic procedure in suspected cases. A 9-year-old girl with diffuse cerebrospinal gliomatosis, investigated with sequential cranial CT scans, and MRI-verified spinal cord involvement is reported, and the corresponding literature is reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Biopsy
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / pathology
  • Child
  • Female
  • Glioma / diagnosis*
  • Glioma / pathology
  • Humans
  • Magnetic Resonance Imaging*
  • Neurologic Examination
  • Spinal Cord Neoplasms / diagnosis*
  • Spinal Cord Neoplasms / pathology
  • Stereotaxic Techniques*
  • Tomography, X-Ray Computed*