The dopaminergic mesencephalic projections to the hippocampal formation in the rat

Prog Neuropsychopharmacol Biol Psychiatry. 1997 Jan;21(1):1-22. doi: 10.1016/s0278-5846(96)00157-1.


1. The dopaminergic mesencephalic neurons projecting to the hippocampal formation are distributed in three cell groups: A8 region in the retrorubral field, A9 region in the substantia nigra and A10 region in the ventral tegmental area. 2. Anterograde and retrograde tract-tracing techniques combined with immunohistochemical procedures indicate a topographical organization of mesencephalic dopaminergic projections towards the hippocampal formation. 3. Electrophysiological evidence suggest that dopaminergic mesencephalic neurons could have a regulatory role in suppressing hippocampal excitability. 4. The functional significance of the mesohippocampal dopaminergic system is largely unknown, although it was suggested that this projection could have a role in methamphetamine-produced hypermotility and in modulation of memory processes.

Publication types

  • Review

MeSH terms

  • Animals
  • Dopamine / metabolism*
  • Hippocampus / anatomy & histology*
  • Hippocampus / metabolism
  • Mesencephalon / anatomy & histology
  • Mesencephalon / metabolism*
  • Rats


  • Dopamine