B cell development under the condition of allelic inclusion

Immunity. 1997 Mar;6(3):225-33. doi: 10.1016/s1074-7613(00)80325-8.


Mice whose IgH alleles are engineered to encode two distinct antibody heavy (H) chains generate a normal-sized B cell compartment in which most cells stably express the two heavy chains. This demonstrates that "toxicity" of bi-allelic H chain expression and cell-autonomous mechanisms of silencing in-frame IgH gene rearrangements do not significantly contribute to allelic exclusion at the IgH locus. Notwithstanding, the stability of the various engineered IgH loci during B cell development in the bone marrow differed substantially from each other.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Animals
  • B-Lymphocytes / cytology*
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / metabolism
  • Cell Compartmentation / immunology
  • Cell Differentiation / genetics
  • Cell Differentiation / immunology
  • Frameshift Mutation / immunology
  • Gene Rearrangement, B-Lymphocyte, Heavy Chain
  • Immunoglobulin Joining Region / genetics
  • Immunoglobulin Variable Region / genetics
  • Mice
  • Mice, Mutant Strains
  • Molecular Sequence Data
  • Polymorphism, Genetic / immunology
  • Receptors, Antigen, B-Cell / metabolism


  • Immunoglobulin Joining Region
  • Immunoglobulin Variable Region
  • Receptors, Antigen, B-Cell

Associated data

  • GENBANK/Z84197
  • GENBANK/Z84198
  • GENBANK/Z84199
  • GENBANK/Z84200