The function of costimulatory molecules and the development of IL-4-producing T cells

Immunol Today. 1997 Mar;18(3):115-20. doi: 10.1016/s0167-5699(97)01005-0.

Abstract

The development of IL-4-producing effector T cells during a type 2 immune response requires signaling through B7 ligands, but probably not CD40 ligands. Here, William Gause and colleagues review the still controversial role of CD28 and CTLA-4 on T cells, and B7-1 and B7-2 on antigen-presenting cells, and provide a model to incorporate recent findings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Abatacept
  • Animals
  • Antigens, CD
  • Antigens, Differentiation
  • B7-1 Antigen
  • B7-2 Antigen
  • CTLA-4 Antigen
  • Communicable Diseases / immunology
  • Humans
  • Immunoconjugates*
  • Interleukin-4 / biosynthesis*
  • Membrane Glycoproteins
  • Models, Biological
  • T-Lymphocytes / immunology*

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • B7-1 Antigen
  • B7-2 Antigen
  • CD86 protein, human
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • Immunoconjugates
  • Membrane Glycoproteins
  • Interleukin-4
  • Abatacept