The T cell receptor beta genes of Xenopus

Eur J Immunol. 1997 Mar;27(3):763-71. doi: 10.1002/eji.1830270327.

Abstract

cDNA of the T cell receptor beta (TCRB) have been isolated from the anuran amphibian Xenopus and they show strong structural homology to TCRB sequences of other vertebrates. Ten BV families, two D segments, ten J segments, and a single C region have been defined so far. Each V family consists of one to two members per haploid genome. A unique feature of the Xenopus TCRB constant region is the lack of N-linked carbohydrate glycosylation sites. The recombination signal sequences suggest that the mechanism of rearrangements are identical to those of mammals. The locus is inherited in a diploid manner despite the pseudotetraploidy of the Xenopus laevis and X. gilli used in this study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blotting, Southern
  • Cloning, Molecular
  • Cysteine / chemistry
  • Gene Expression
  • Gene Rearrangement, beta-Chain T-Cell Antigen Receptor*
  • Genes
  • Glycosylation
  • Molecular Sequence Data
  • Multigene Family
  • Phylogeny
  • RNA, Messenger / genetics
  • Receptors, Antigen, T-Cell, alpha-beta / genetics*
  • Regulatory Sequences, Nucleic Acid
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Xenopus laevis / genetics*

Substances

  • RNA, Messenger
  • Receptors, Antigen, T-Cell, alpha-beta
  • Cysteine

Associated data

  • GENBANK/U60424
  • GENBANK/U60425
  • GENBANK/U60426
  • GENBANK/U60427
  • GENBANK/U60428
  • GENBANK/U60429
  • GENBANK/U60430
  • GENBANK/U60431
  • GENBANK/U60432
  • GENBANK/U60433
  • GENBANK/U60434
  • GENBANK/U60435
  • GENBANK/U60436
  • GENBANK/U75994