Comparison of uptake of 99mTc-alkylisonitriles in the rat 9L gliosarcoma tumor model

Nucl Med Biol. 1997 Jan;24(1):21-5. doi: 10.1016/s0969-8051(96)00152-7.


The accumulation of three 99mTc(I) alkyl isonitriles was compared in vitro and in vivo using 9L gliosarcoma cells. In vitro, the uptake of 99mTc-EIBI and 99mTc-EPI was higher than that of 99mTc-MIBI. In vivo, however, there was no difference in the tumor concentration at 15 or 60 min postinjection and only a small difference at 24 h. The differences in uptake observed in vitro are apparently offset in vivo by differences in delivery of the tracers to the tumor.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / metabolism*
  • Gliosarcoma / diagnostic imaging
  • Gliosarcoma / metabolism*
  • Male
  • Nitriles / pharmacokinetics*
  • Organotechnetium Compounds / pharmacokinetics*
  • Radionuclide Imaging
  • Rats
  • Technetium Tc 99m Sestamibi / pharmacokinetics*
  • Tissue Distribution
  • Tumor Cells, Cultured


  • Nitriles
  • Organotechnetium Compounds
  • technetium Tc 99m ethoxypropylisonitrile
  • technetium Tc 99m ethoxyisobutylisonitrile
  • Technetium Tc 99m Sestamibi