Adenosine induced polymorphic ventricular tachycardia in adults without structural heart disease

Pacing Clin Electrophysiol. 1997 Mar;20(3 Pt 1):743-5. doi: 10.1111/j.1540-8159.1997.tb03897.x.


Adenosine has been reported to cause polymorphic VT in patients with congenital or acquired prolonged QT intervals and to cause pause dependent VT in a patient with a normal QT interval. There have been no previous reports of adenosine causing nonpause dependent polymorphic VT in patients without structural heart disease. We report two patients, with normal hearts and normal QT intervals, who developed nonsustained polymorphic VT that was not pause dependent. Adenosine induced polymorphic VT does not appear to be a marker of the long QT syndrome, but may be an uncommon yet not unexpected pharmacological response to drug administration.

Publication types

  • Case Reports

MeSH terms

  • Adenosine / adverse effects*
  • Adenosine / therapeutic use
  • Adult
  • Anti-Arrhythmia Agents / adverse effects*
  • Anti-Arrhythmia Agents / therapeutic use
  • Electrocardiography
  • Female
  • Humans
  • Middle Aged
  • Tachycardia, Supraventricular / drug therapy
  • Tachycardia, Ventricular / chemically induced*
  • Tachycardia, Ventricular / physiopathology


  • Anti-Arrhythmia Agents
  • Adenosine