Interactions between enteropathogenic Escherichia coli and host epithelial cells

Trends Microbiol. 1997 Mar;5(3):109-14. doi: 10.1016/S0966-842X(97)01000-7.


The pathogenesis of enteropathogenic Escherichia coli (EPEC) infection is emerging as a paradigm for a multistage microorganism-host cell interaction. Both type IV fimbriae and a type III secretion apparatus play principal roles in interactions between the bacteria and host cells. Recent data suggest that bacteria-induced signal transduction activates the receptor that allows tenacious adherence of the bacteria to the host cell surface.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacterial Adhesion
  • Bacterial Proteins / metabolism
  • Diarrhea / microbiology
  • Diarrhea / physiopathology
  • Epithelial Cells
  • Escherichia coli / pathogenicity*
  • Humans
  • Signal Transduction
  • Virulence


  • Bacterial Proteins