Cytogenetics and molecular genetics in multiple myeloma

Hematol Oncol Clin North Am. 1997 Feb;11(1):1-25. doi: 10.1016/s0889-8588(05)70412-3.


Specific cytogenetic abnormalities have been identified in multiple myeloma that confer a poor prognosis, even with intensive chemotherapy and autotransplants. The identification and characterization of potential genes involved in these different chromosomal changes and their interplay with oncogenes and tumor suppressor genes controlling cellular growth and apoptosis is the major focus of this review.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Chromosome Aberrations
  • Humans
  • Multiple Myeloma / genetics*