Late onset corneal haze after photorefractive keratectomy for moderate and high myopia

Ophthalmology. 1997 Mar;104(3):369-73; discussion 373-4. doi: 10.1016/s0161-6420(97)30306-6.


Background: Corneal haze after photorefractive keratectomy (PRK) usually appears within 4 weeks after the procedure. A new type of corneal haze, starting relatively late after PRK, is reported.

Methods: The authors reviewed the files of their first 1000 consecutive patients who completed a follow-up of 12 months or more and identified all those who had clear corneas for at least 4 months, after which corneal haze appeared. The clinical course in these patients was evaluated.

Results: Late onset corneal haze (LOCH) had occurred in 18 eyes of 17 patients (incidence, 1.8%), appearing 4 to 12 months after PRK and resulting in decreased visual acuity and regression. Treatment with topical steroids or reoperation resulted in partial reversibility of haze and regression.

Conclusions: A new entity of LOCH is described. The appearance of LOCH suggests that corneal healing and remodeling continue for at least 1 year after PRK.

MeSH terms

  • Administration, Topical
  • Adult
  • Anti-Inflammatory Agents / therapeutic use
  • Cornea / physiopathology
  • Cornea / surgery*
  • Corneal Opacity / etiology*
  • Corneal Opacity / physiopathology
  • Corneal Opacity / therapy
  • Dexamethasone / therapeutic use
  • Female
  • Follow-Up Studies
  • Glucocorticoids
  • Humans
  • Lasers, Excimer
  • Male
  • Middle Aged
  • Myopia / physiopathology
  • Myopia / surgery*
  • Ophthalmic Solutions
  • Photorefractive Keratectomy / adverse effects*
  • Reoperation
  • Retrospective Studies
  • Visual Acuity
  • Wound Healing / physiology


  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Ophthalmic Solutions
  • Dexamethasone