Wound healing--aiming for perfect skin regeneration

Science. 1997 Apr 4;276(5309):75-81. doi: 10.1126/science.276.5309.75.


The healing of an adult skin wound is a complex process requiring the collaborative efforts of many different tissues and cell lineages. The behavior of each of the contributing cell types during the phases of proliferation, migration, matrix synthesis, and contraction, as well as the growth factor and matrix signals present at a wound site, are now roughly understood. Details of how these signals control wound cell activities are beginning to emerge, and studies of healing in embryos have begun to show how the normal adult repair process might be readjusted to make it less like patching up and more like regeneration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Coagulation
  • Cicatrix / etiology
  • Endopeptidases / metabolism
  • Epidermal Cells
  • Epidermis / embryology
  • Epithelial Cells
  • Epithelium / physiology
  • Growth Substances / physiology
  • Hair / physiology
  • Humans
  • Keratinocytes / physiology
  • Keratins / physiology
  • Leukocytes / physiology
  • Neovascularization, Physiologic
  • Regeneration*
  • Skin / blood supply
  • Skin / embryology
  • Skin / innervation
  • Skin Physiological Phenomena*
  • Sweat Glands / physiology
  • Transforming Growth Factor beta / physiology
  • Wound Healing*


  • Growth Substances
  • Transforming Growth Factor beta
  • Keratins
  • Endopeptidases