Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Eur J Biochem. 1977 Jul 1;77(1):31-6. doi: 10.1111/j.1432-1033.1977.tb11637.x.
No abstract available

MeSH terms

  • Acetates / metabolism
  • Animals
  • Binding, Competitive
  • Caprylates / metabolism
  • Cholesterol / biosynthesis*
  • Fatty Acids / biosynthesis
  • Gallbladder / metabolism
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors*
  • In Vitro Techniques
  • Kidney / metabolism
  • Kinetics
  • Lactones / pharmacology
  • Liver / drug effects
  • Liver / metabolism*
  • Lovastatin / analogs & derivatives
  • Male
  • Mevalonic Acid / metabolism
  • Mice
  • Naphthalenes / pharmacology*
  • Naphthols
  • Organ Specificity
  • Pyrans / pharmacology
  • Rats
  • Sterols / biosynthesis

Substances

  • Acetates
  • Caprylates
  • Fatty Acids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Lactones
  • Naphthalenes
  • Naphthols
  • Pyrans
  • Sterols
  • mevastatin
  • ML 236A
  • Cholesterol
  • Lovastatin
  • Mevalonic Acid