Relationship between interleukin-8 levels and myeloperoxidase activity in human gastric mucosa

J Gastroenterol Hepatol. 1997 Feb;12(2):104-8. doi: 10.1111/j.1440-1746.1997.tb00392.x.


Although interleukin (IL)-8 is well known as a chemotactic agent for neutrophil migration in vitro, the relationship between IL-8 activity and the degree of neutrophil infiltration in gastric mucosa is still unclear. In the present study, we investigated IL-8 and myeloperoxidase activity, a marker of neutrophil infiltration, in gastric antral mucosa using biopsy samples in 23 patients with no gastric lesions. The results indicate that there is a good correlation between IL-8 and myeloperoxidase activity (y = 0.173x + 13.9; r = 0.49, P < 0.01). Furthermore, IL-8 and myeloperoxidase activity are significantly higher in Helicobacter pylori-positive patients than in H. pylori-negative patients. In conclusion, an increase of IL-8 activity in the gastric mucosa causes increased neutrophil infiltration in human gastric mucosa and H. pylori infection accelerates these reactions in the mucosa.

MeSH terms

  • Aged
  • Campylobacter / isolation & purification
  • Female
  • Gastric Mucosa / enzymology*
  • Gastric Mucosa / microbiology
  • Helicobacter pylori / isolation & purification
  • Humans
  • Interleukin-8 / blood*
  • Male
  • Middle Aged
  • Peroxidase / metabolism*


  • Interleukin-8
  • Peroxidase