Elevation of serum xanthine oxidase activity following halothane anesthesia in man

Experientia. 1977 Oct 15;33(10):1356-8. doi: 10.1007/BF01920178.


Halothane, but not methoxyflurane, was found to cause specific hepatocellular damage, the hepatotoxicity being prompt but transient. The hepatotoxicity was demonstrated by the elevation in the serum activity of xanthine oxidase, a highly sensitive marker for acute liver damage.

MeSH terms

  • Anesthesia*
  • Aspartate Aminotransferases / blood
  • Halothane / pharmacology*
  • Humans
  • L-Lactate Dehydrogenase / blood
  • Methoxyflurane / pharmacology
  • Time Factors
  • Xanthine Oxidase / blood*


  • Methoxyflurane
  • L-Lactate Dehydrogenase
  • Xanthine Oxidase
  • Aspartate Aminotransferases
  • Halothane