Effect of the basidiomycete Poria cocos on experimental dermatitis and other inflammatory conditions

Chem Pharm Bull (Tokyo). 1997 Mar;45(3):492-4. doi: 10.1248/cpb.45.492.

Abstract

The hydroalcoholic extract from P. cocos was examined for oral and topical anti-inflammatory activities. It proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (TPA) acute edemas, TPA chronic inflammation and oxazolone delayed hypersensitivity in mice. Two lanostane-type triterpenes were isolated and identified by spectroscopic methods as dehydrotumulosic and pachymic acids. Their ID50 on acute TPA edema was 4.7 x 10(-3) and 6.8 x 10(-4) mumol/ear, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Administration, Topical
  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / therapeutic use*
  • Arachidonic Acid / pharmacology
  • Basidiomycota / chemistry*
  • Carrageenan / pharmacology
  • Dermatitis / drug therapy*
  • Female
  • Inflammation / drug therapy*
  • Mice
  • Plant Extracts / therapeutic use*
  • Tetradecanoylphorbol Acetate / pharmacology
  • Triterpenes / administration & dosage
  • Triterpenes / therapeutic use

Substances

  • Anti-Inflammatory Agents
  • Plant Extracts
  • Triterpenes
  • Arachidonic Acid
  • Carrageenan
  • Tetradecanoylphorbol Acetate