Outcome of unstable angina in patients with diabetes mellitus

Diabet Med. 1997 Mar;14(3):209-13. doi: 10.1002/(SICI)1096-9136(199703)14:3<209::AID-DIA324>3.0.CO;2-B.

Abstract

This prospective hospital-based, case-control study compares the outcome of unstable angina in non-insulin dependent diabetic patients and non-diabetic control subjects. One hundred and sixty-two diabetic patients and 162 non-diabetic control patients with unstable angina were entered into the study. The 3-month mortality was 8.6% (95% confidence interval, CI = 4.4-12.9%) in diabetic patients and 2.5% (CI = 0.1-4.9%) in control patients (p = 0.014). The 1-year mortality was 16.7% (CI = 10.9%-22.4%) in diabetic patients and 8.6% (CI = 4.4%-12.9%) in non-diabetic patients (p = 0.029). Diabetic patients received beta-blockade and underwent coronary angiography and angioplasty less frequently than controls; the frequency of unstable angina, of acute myocardial infarction, and coronary artery bypass grafting was similar in both groups at 1 year of follow-up. It is concluded that diabetic patients with unstable angina have a higher mortality than non-diabetic patients and that this difference is largely accounted for by early (first 3 months) mortality.

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use
  • Aged
  • Angina, Unstable / epidemiology
  • Angina, Unstable / mortality
  • Angina, Unstable / therapy*
  • Angioplasty
  • Aspirin / therapeutic use
  • Calcium Channel Blockers / therapeutic use
  • Case-Control Studies
  • Confidence Intervals
  • Coronary Angiography
  • Coronary Artery Bypass / statistics & numerical data
  • Coronary Disease / genetics
  • Diabetic Angiopathies / epidemiology
  • Diabetic Angiopathies / mortality
  • Diabetic Angiopathies / therapy*
  • Digoxin / therapeutic use
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Myocardial Infarction / epidemiology
  • Nitrates / therapeutic use
  • Prospective Studies
  • Risk Factors
  • Time Factors

Substances

  • Adrenergic beta-Antagonists
  • Calcium Channel Blockers
  • Nitrates
  • Digoxin
  • Aspirin