A color spot test for the detection of Kryptofix 2.2.2 in [18F]FDG preparations

Nucl Med Biol. 1997 Feb;24(2):193-5. doi: 10.1016/s0969-8051(96)00212-0.

Abstract

A color spot test is described that can confirm the absence of Kryptofix 2.2.2 in 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) in less than 5 min. Pretreated strips of plastic-backed silica gel 60 thin-layer chromatographic medium, saturated with iodoplatinate reagent, are over-spotted with separate droplets of final product [18F]FDG and Kryptofix standard solutions. A blue-black circular spot is clearly visible at Kryptofix concentrations as low as 2 micrograms/mL.

Publication types

  • Comparative Study

MeSH terms

  • Bridged Bicyclo Compounds, Heterocyclic / analysis*
  • Chelating Agents / analysis
  • Chromatography, Thin Layer / methods
  • Colorimetry / methods
  • Deoxyglucose / analogs & derivatives*
  • Deoxyglucose / chemistry
  • Deoxyglucose / standards
  • Fluorine Radioisotopes*
  • Fluorodeoxyglucose F18
  • Indicators and Reagents
  • Reagent Strips

Substances

  • Bridged Bicyclo Compounds, Heterocyclic
  • Chelating Agents
  • Fluorine Radioisotopes
  • Indicators and Reagents
  • Reagent Strips
  • Fluorodeoxyglucose F18
  • cryptating agent 222
  • Deoxyglucose