Low-voltage-activated T-type Ca2+ channels

Trends Pharmacol Sci. 1997 Feb;18(2):37-42. doi: 10.1016/s0165-6147(96)01021-8.


Although progress in our understanding of T channels and their physiological role has been slower than with other Ca2+ channels, it was clear during this two-day workshop that interest and research in the field remain very intense. Advances have been hampered by many factors: small current amplitude, lack of pharmacological tools, apparent heterogeneity, and lack of a cloned channel. Nevertheless, many interesting roles for T channels have been described, which point to a generally subtle modulatory action. Furthermore, recent results suggest that the above barriers might soon be abolished: new pharmacological tools (mibefradil and newer generation compounds) with T-channel selectivity are being developed and many groups claim to be close to cloning a T channel.

Publication types

  • Congress

MeSH terms

  • Animals
  • Calcium Channel Blockers / administration & dosage
  • Calcium Channel Blockers / pharmacology*
  • Calcium Channel Blockers / therapeutic use
  • Calcium Channels / classification
  • Calcium Channels / drug effects
  • Calcium Channels / physiology*
  • Cell Communication / physiology
  • Cell Division / physiology
  • Cloning, Molecular
  • Electrophysiology
  • Exons
  • Humans
  • Rats


  • Calcium Channel Blockers
  • Calcium Channels