Is pregnancy smoking causal to testis cancer in sons? A hypothesis

Acta Oncol. 1997;36(1):59-63. doi: 10.3109/02841869709100734.

Abstract

Inquiry studies into smoking during pregnancy as a possible cause of testis cancer in sons are found misinterpreted as purely negative. Danish quinquennial incidence rates for patients aged 25-39 years are compared with rates for tobacco-induced neoplasms among the corresponding maternal generation, primarily of bladder tumours including papillomas, and of lung both for ages 50-64 years, allowing for period of latency. Corresponding to a delay of increase, earlier demonstrated for incidence rates of testis cancer among men born 1939-1945, delays of increase are found for female bladder and lung with allowance for lag-times of 30 and 20 years respectively. Comparison of data from Scandinavian nationwide cancer registries show a noteworthy parallelism of trends from first to last plotting of testis/female bladder ratios. The rise for lung is found steeper in consequence of age distribution.

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Incidence
  • Lung Neoplasms / epidemiology
  • Lung Neoplasms / etiology
  • Male
  • Middle Aged
  • Pregnancy
  • Pregnancy Complications*
  • Registries
  • Risk
  • Scandinavian and Nordic Countries / epidemiology
  • Smoking / adverse effects*
  • Testicular Neoplasms / epidemiology*
  • Testicular Neoplasms / etiology*
  • Urinary Bladder Neoplasms / epidemiology
  • Urinary Bladder Neoplasms / etiology