Joint manifestation in Lyme disease hare shown similarities to those in reactive arthritis. SAPHO syndrome can also be included into the group of seronegative spondyloarthrophaties. It is presented a patient with joint, ocular and serological features proper of Lyme disease and after ones suggestive of SAPHO syndrome, who responds properly to an antibiotic treatment. It is considered the possibility that some patients suffering from SAPHO syndrome can also be suffering from Lyme disease.