Prevalence of iron deficiency in the United States

JAMA. 1997 Mar 26;277(12):973-6. doi: 10.1001/jama.1997.03540360041028.

Abstract

Objective: To determine the prevalence of iron deficiency and iron deficiency anemia in the US population.

Design: Nationally representative cross-sectional health examination survey that included venous blood measurements of iron status.

Main outcome measures: Iron deficiency, defined as having an abnormal value for at least 2 of 3 laboratory tests of iron status (erythrocyte protoporphyrin, transferrin saturation, or serum ferritin); and iron deficiency anemia, defined as iron deficiency plus low hemoglobin.

Participants: A total of 24,894 persons aged 1 year and older examined in the third National Health and Nutrition Examination Survey (1988-1994).

Results: Nine percent of toddlers aged 1 to 2 years and 9% to 11% of adolescent girls and women of childbearing age were iron deficient; of these, iron deficiency anemia was found in 3% and 2% to 5%, respectively. These prevalences correspond to approximately 700,000 toddlers and 7.8 million women with iron deficiency; of these, approximately 240,000 toddlers and 3.3 million women have iron deficiency anemia. Iron deficiency occurred in no more than 7% of older children or those older than 50 years, and in no more than 1% of teenage boys and young men. Among women of childbearing age, iron deficiency was more likely in those who are minority, low income, and multiparous.

Conclusion: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age.

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Aged
  • Anemia, Iron-Deficiency / blood
  • Anemia, Iron-Deficiency / epidemiology*
  • Blood Chemical Analysis
  • Child
  • Child, Preschool
  • Female
  • Ferritins / blood
  • Humans
  • Infant
  • Iron / blood
  • Iron / deficiency*
  • Male
  • Middle Aged
  • Nutrition Surveys
  • Prevalence
  • Protoporphyrins / blood
  • Sex Distribution
  • Transferrin / analysis
  • United States / epidemiology

Substances

  • Protoporphyrins
  • Transferrin
  • Ferritins
  • Iron