The TNF2 allele does not contribute towards susceptibility to systemic lupus erythematosus

Immunol Lett. 1997 Jan;55(1):1-3. doi: 10.1016/s0165-2478(96)02635-1.


The uncommon allele (TNF2) of a polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-alpha) gene has been reported to be increased in Caucasian systemic lupus erythematosus (SLE) patients (associated with HLA-DR3). To investigate whether TNF2 contributes towards susceptibility to Chinese SLE patients (not associated with HLA-DR3), 100 patients with SLE and 107 controls were studied. The frequency of TNF2 allele in controls was 0.140. There was a strong association between TNF2 allele and HLA-DR3 (P < 10(-8)) in controls. The frequency of TNF2 allele in SLE patients was 0.15. There was no difference in frequencies of TNF2 allele between patients and controls. This finding strongly suggests that TNF2 does not play a direct role in the susceptibility of SLE.

MeSH terms

  • Alleles
  • Asian Continental Ancestry Group / genetics
  • Autoimmune Diseases / genetics*
  • China
  • Disease Susceptibility
  • European Continental Ancestry Group / genetics
  • Female
  • Gene Frequency
  • Genotype
  • HLA-DR3 Antigen / genetics
  • Humans
  • Lupus Erythematosus, Systemic / genetics*
  • Male
  • Tumor Necrosis Factor-alpha / genetics*


  • HLA-DR3 Antigen
  • Tumor Necrosis Factor-alpha