Architecture and function in the muscle sarcomere

Curr Opin Struct Biol. 1997 Apr;7(2):247-57. doi: 10.1016/s0959-440x(97)80033-4.


Striated muscle sarcomeres in vertebrates comprise ordered arrays of actin and myosin filaments, organized by an elaborate protein scaffold. Recent innovative work in a number of laboratories has greatly improved our knowledge of these structures, their organization and their interactions. Structural details have been reported on myosin filaments, actin filaments, Z-bands, M-bands, titin, and nebulin. Time-resolved X-ray diffraction and electron microscopy are revealing the molecular movements involved in force production and regulation.

Publication types

  • Review

MeSH terms

  • Actins / ultrastructure
  • Animals
  • Carrier Proteins / ultrastructure
  • Connectin
  • Models, Molecular
  • Muscle Contraction
  • Muscle Proteins / ultrastructure*
  • Muscles / ultrastructure
  • Myosins / ultrastructure
  • Protein Kinases / ultrastructure
  • Sarcomeres / ultrastructure*
  • X-Ray Diffraction


  • Actins
  • Carrier Proteins
  • Connectin
  • Muscle Proteins
  • Protein Kinases
  • Myosins