Nucleotide sequences of 5'-terminal ribosome-protected initiation regions from two reovirus messages

Nature. 1977 Sep 29;269(5627):391-4. doi: 10.1038/269390a0.


Sequences for two reovirus ribosome-protected fragments are presented. Comparison with four other reovirus initiation sites reveals only two common features: the 5'-terminal sequence m7GpppGmCUA, and (located 15-33 nucleotides from the cap) the sequence AUGG. Both the cap and the AUG codon are included in the 40S-ribosome protected region from all six reovirus messages.

MeSH terms

  • Base Sequence
  • Binding Sites
  • Codon
  • Guanosine Pentaphosphate / metabolism
  • Peptide Chain Initiation, Translational*
  • RNA, Messenger* / isolation & purification
  • RNA, Messenger* / metabolism
  • RNA, Viral* / isolation & purification
  • RNA, Viral* / metabolism
  • Reoviridae / metabolism*
  • Ribosomes / metabolism*


  • Codon
  • RNA, Messenger
  • RNA, Viral
  • Guanosine Pentaphosphate