A patient with Wegener's granulomatosis presenting with a subarachnoid hemorrhage: case report and review of CNS disease associated with Wegener's granulomatosis

Am J Nephrol. 1997;17(2):181-6. doi: 10.1159/000169095.


Up to 54% of the patients with Wegener's granulomatosis (WG) experience neurological manifestations at some point during the course of their disease. However, the central nervous system is involved in less than 10% of the patients. There have only been 4 reported cases of subarachnoid hemorrhage complicating WG. We now report the 1st patient with a clinical picture and histopathologic features consistent with WG presenting with a subarachnoid hemorrhage. Another unusual feature of this case is that perinuclear staining rather than cytoplasmic staining antineutrophil cytoplasmic autoantibodies were positive. The literature on central nervous involvement in WG is reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Antibodies, Antineutrophil Cytoplasmic / analysis
  • Central Nervous System Diseases / etiology*
  • Granulomatosis with Polyangiitis / complications*
  • Humans
  • Kidney Glomerulus / pathology
  • Male
  • Subarachnoid Hemorrhage / etiology*


  • Antibodies, Antineutrophil Cytoplasmic